![]() Therefore, it should not be used in pregnancy unless absolutely indicated. Its safety in human pregnancy has not been established. Local phlebitis occurs rarely following intravenous administration but can be minimized by slow injections over 2-4 minutes. A few side effects such as gastro-intestinal effects including diarrhea, nausea and vomiting, stomatitis and glossitis cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia hepatic reactions including elevations of SGOT or SGPT, bilirubinemia CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness were reported. However, it maintains potency for at least 6 hours at room temperature or 24 hours at 5☌).Ĭeftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics.Ĭeftriaxone is generally well tolerated. (The use of freshly reconstituted solution is recommended. Before starting treatment through Ceftriaxone injection, patient tolerance test should be checked by administration of a test dose. The injection should be administered over 2-4 minutes, by Intramuscular or Intravenous injection or by tubing infusion over a period of 30 minutes at concentration between 10 mg/mL and 40 mg/mL. For Intravenous Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in 5 ml of Water for injection or 1 g Ceftriaxone in 10 ml of Water for injection USP or 2 g Ceftriaxone in 20 ml of Water for injection.For Intramuscular Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in 2 ml Lidocaine HCI 1% injection or 1 g Ceftriaxone in 3.5 ml of Lidocaine HCI 1% injection.Preparation of Solutions for Intramuscular / Intravenous Injections: Usual duration is 4 to 14 days in complicated infections, longer therapy may be required. Meningitis: 100 mg/kg IV or IM in single daily dose or (or in equally divided doses twice a day) Maximum dose: 4 gm/dayĭuration of therapy: Continue for more than 2 days after signs and symptoms of infection have disappeared.Acute bacterial otitis media: 50 mg/kg IM in single dose Maximum dose: 1 gm/day.Pneumonia, Bronchitis, Skin and skin structure infection, Urinary tract infections, Bacterial Septicemia, Bone and joint infections: 50 to 75 mg/kg IV or IM once a day (or in equally divided doses twice a day) Maximum dose: 2 gm/day.Infants and Children (01 month or older): The usual dose is 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day). Surgical prophylaxis: 1 g IV as a single dose 30 to 120 minutes before surgery.Uncomplicated gonococcal infections: 250 mg IM as a single dose.Pneumonia, Bronchitis, Acute bacterial otitis media, Skin and skin structure infection, Urinary tract infections, Bacterial Septicemia, Bone and joint infections, Meningitis: 1 to 2 g IV or IM once a day (or in equally divided doses twice a day) Maximum dose: 4 gm/day. ![]() The drug is highly protein bound (95%).Īdult: The usual dose is 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day). About 40-65% of a dose of Ceftriaxone is excreted unchanged in the urine the remainder is excreted in the bile and ultimately found in the feces as unchanged drug and microbiologically inactive compound. Ceftriaxone is not metabolized in the body. A remarkable feature of Ceftriaxone is its relatively long plasma elimination half-life of about 6 to 9 hours, which makes single or once-daily dosage of the drug appropriate for most patients. Ceftriaxone has a high degree of stability in the presence of beta lactamases. Like other cephalosporins and penicillins, Ceftriaxone kills bacteria by interfering with the synthesis of the bacterial cell wall. ![]() It has potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. Perioperative prophylaxis of infections associated with surgeryĬeftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic. ![]() Ceftriaxone is indicated for the treatment of the following major infections:
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